Amin Akhshi

Graduate Student
McGill Univ
Email author

Investigating the mechanisms underlying synchronization in sensory neural populations during burst firing

Amin Akhshi, Anmar Khadra, Maurice Chacron

 

I’m a PhD student in Department of Physiology at McGill University under supervision of Dr Khadra and Dr Chacron. My research involves studying population coding in electrosensory system of the weakly electric fish Apteronotus leptorhynchus using computational models that capture the intrinsic dynamics of burst firing and modifying them to include all the components involved in calcium mobilization across the cell and ER membranes, including the various calcium channels and (PMCA and SERCA) pumps. In addition, I use bifurcation theory to determine the effects of key parameters (e.g., synaptic conductance, FWHM of synaptic input, depolarizing bias current) on dynamics and use slow-fast analysis to decipher the effects of calcium on not only bursting but also on inducing synchrony.

Investigating the mechanisms underlying synchronization in sensory neural populations during burst firing

Amin Akhshi, Anmar Khadra, Maurice Chacron
Abstract

It is now generally agreed that perception and behavior is determined by integrating the activities of large neural populations. As such, it has become necessary to understand how neural populations encode incoming sensory input (i.e., population coding). Such population coding has been greatly complicated by the fact that neural activities are not independent of one another (i.e., are correlated). Here, we used a mathematical model to better understand how electrosensory system codes for input information and how intrinsic properties of single neurons influence their activities at the population level. Overall, we discussed about how an intrinsic burst firing mechanism at the single neuron influences population coding via synchrony. This will provide new insight on mechanisms that regulate synchronous burst firing that will help to understand population coding in a mathematical basis.